Niacinamide 5.0

Highly concentrated serum with Niacinamide. An active serum to reduce redness and itching due to dry skin, the appearance of pigmentation and impurities. Niacinamide is one of the most widely studied topical skincare ingredients. Numerous peer-reviewed studies have revealed its many benefits on the skin, which include clinically proven efficacy to brighten the skin, reduce acne and blemishes, improve the skin barrier and rebalance the skin’s microbiome.

– Has a positive effect to reduce skin pigmentation to deliver a more uniform skin tone appearance. e. It helps to stop the transfer of existing melanin from melanocytes to keratinocytes. In addition to inhibiting melanosome transfer, niacinamide has also been reported to interfere with the initiation of melanin synthesis regulated by messenger molecules, α-MSH and endothelin-1, secreted by keratinocytes.

– Provides a significant positive effect on AQP3 expression thus improving skin hydration. The family of transport proteins, Aquaporins (AQP), moves water and small solutes across cell membranes.

– Niacinamide positively affects the expression of proteins critical to skin moisture, such as filaggrin, involucrin, and keratin. It also improves the skin’s lipid composition by increasing ceramide production.

– Regulates the skin microbiome by reducing the level and growth of C. acnes. Niacinamide is reducing the appearance of blemishes through a twice-daily application of a 5% niacinamide serum, with the efficacy skewed toward subjects with oily skin.